Based on Pentium(R) 4 CPU 3.40GHz, 1G RAM

1)  Rigid-based registration
Setting for regular and large:
           Transformation: rigid
           Interpolation: linear
           Similarity: MI
           Others: default

Source     regular.IM0 (size Rmem) |  large.IM0 (size Lmem)
Target     regularrigid.IM0        |  largerigid.IM0
Time          1 min                |    28 min
Memory        3 Rmem               |    3 Lmem


2)  Affine-based registration
Setting for regular and large:
           Transformation: rigid + scale
           Interpolation: linear
           Similarity: MI
           Others: default

Source     regular.IM0 (size Rmem) |  large.IM0 (size Lmem)
Target     regularaffine.IM0       |  largeaffine.IM0
Time          1 min                |    25 min
Memory        3 Rmem               |    3 Lmem


3)  Deformable-based registration
Setting for regular: default
Setting for large:
           Converge rate: 30
           Pyramid level: 7
           Step size: 73
           Control spacing: 15

Source     regular.IM0 (size Rmem) |  large.IM0 (size Lmem)
Target     regularffd.IM0          |  largeffd.IM0
Time          1 min                |    57 min
Memory        4 Rmem               |    4 Lmem